Acetaminophen and codeine phosphate tablets may impair the psychological or physical abilities required to accomplish possibly harmful actions like driving a vehicle or functioning machinery.
Avoid using acetaminophen and codeine phosphate tablets in adolescents 12 to eighteen yrs of age who have other possibility variables that could improve their sensitivity for the respiratory depressant effects of codeine Except the advantages outweigh the risks.
Interactions with Medications Impacting CYP450 Isoenzymes: The effects of concomitant use or discontinuation of CYP450 3A4 inducers/inhibitors or CYP450 2D6 inhibitors are sophisticated; concomitant use needs very careful thing to consider of the effects over the dad or mum drug, codeine, as well as the Lively metabolite, morphine.
The chance is greater in kids who're obese or have breathing troubles, or right after selected surgical procedures (together with tonsil/adenoid elimination). Talk to your health care provider or pharmacist about the hazards and great things about this medication.
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If one particular just isn't available, you could eliminate Acetaminophen and Codeine Phosphate Tablets, USP by mixing the item with Dust, cat litter, or espresso grounds; placing the combination in a sealed plastic bag, and throwing the bag with your trash.
If you utilize this medication while you're pregnant, your infant could become dependent on the drug. This could cause existence-threatening withdrawal signs and symptoms in the baby just after it is actually born.
Patients ought to realize the dangers of lifestyle-threatening respiratory despair and when this risk is finest, patients ought to be aware that a genetic mutation may bring about bigger toxicity in certain clients; clients and caregivers must be instructed to acquire emergency aid immediately if an excessive amount of drug is taken or if respiratory problems occur.
Advise sufferers and caregivers that most likely lethal additive effects could come about if acetaminophen and codeine phosphate tablets are used with benzodiazepines or other CNS depressants, like Alcoholic beverages, more info and not to utilize these medications concomitantly Except supervised by a healthcare provider (see WARNINGS and Safety measures, Drug Interactions).
Risk of Medication Faults: Be certain accuracy when prescribing, dispensing, and administering the oral Answer; dosing errors as a consequence of confusion involving mg and mL, as well as other codeine options of various concentrations may result read more in accidental overdose and Loss of life.
Prolonged-phrase research in mice and rats have already been finished with the National Toxicology website Program To judge the carcinogenic potential of acetaminophen. In 2-calendar year here feeding studies, F344/N rats and B6C3F1 mice have been fed get more info a food plan made up of acetaminophen as much as 6000 ppm. Female rats demonstrated equivocal proof of carcinogenic exercise based upon enhanced incidences of mononuclear cell leukemia at 0.
Like other narcotic medicines, codeine can slow your breathing. Dying may perhaps manifest if respiratory gets way too weak.
Other agony relievers (which include naproxen, ibuprofen) could also be prescribed with this medication. Inquire your medical doctor or pharmacist about making use of this merchandise safely and securely with other medications.